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IARI - RKMP Associated Partners
 

Bioinformatics Tools Used in Plant Genomics & Molecular Breeding
 
Applications Softwares

Vector trimming, quality checking & assembly of high-throughput  genome sequences 

Phred, Phrap & Consed

Sequence Annotation & Assembly

BioEdit, MEGA , DNASTAR & Softberry: FGNESH

Multiple nucleotide & protein sequence alignment

CLUSTALW, BioEdit , DNASTAR & MEGA

Nucleotide & protein sequence homology searches

BLASTN, Mega-BLAST, BLASTX, BLASTP:       On-Line BLAST (NCBI, EMBL & DDBJ) & Local  BLAST (DNASTAR & BioEdit)

In silico microsatellite repeat-motifs mining & Primer designing 

SSRIT - GRAMENE, BatchPrimer3 - USDA & MISA- Gatersen Lab 

PCR primer designing: Standard PCR, multiplex PCR, Allele specific SNP primers, Q-PCR & Probe designing

Primer3, Fast PCR, IDT Q-PCR assay & BatchPrimer3

Marker based genetic diversity analysis & determination of phylogenetic relationships

NTSYSpc, TREECON, PowerMarker, PAUP & PAML

Sequence based molecular diversity analysis & phylogenetics

MEGA, DNASTAR, BioEdit & CLUSTALW  

Bootstrap analysis to determine confidence limits of dendrogram

WinBoot, MEGA, DNASTAR, TREECON & TreeView

Nucleotide diversity, synonymous & non-synonymous substitutions (SNPs), genetic distance & phylogeny

MEGA, DNaSP & PAML

Population genetic structure

STRUCTURE

Mutation models (like Step-wise) of microsatellites

Bottleneck & Darwin

Allele frequency, PIC, Haplotype frequency, LD based association mapping & phylogenetic analysis

PowerMarker, MEGA, DNaSp & GGT

Kinship coefficient & population allele frequency

SPAGeDi, STRUCTURE, PowerMarker & GGT

LD based association mapping of genes/QTLs for complex traits 

TASSEL, PowerMarker & GGT

Construction of genome maps (Gene/QTL mapping)

MAPMAKER, MapQTL, WinQTL, PowerMarker & GGT  

Graphically representing the genetic & physical linkage map on chromosomes  using the  markers & QTLs

MapChart & Graphical GenoTypes (GGT)

Detection of sequence variants/mutations (SNPs & InDels) for TILLING

Autosnip, PolyPhred, MEGA & CODDLE

Conversion of SNPs to cost-effective CAPS markers

SNP2CAPS, NEB Cutter, BioEdit, DNASTAR & dCAPS Finder

Normalization, clustering, PCA, Differential expression, & gene ontology & pathway analysis of Affymetrix GeneChip Microarray data

GeneSpring GX

 
     
 
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